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KMID : 1161520190230020082
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Animal Cells and Systems
2019 Volume.23 No. 2 p.82 ~ p.89
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MiR-15b can target insulin receptor to regulate hepatic insulin signaling in mice
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Li Wei-Dong
Xia Jin-Rong
Lian Yan-Shu
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Abstract
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Now diabetes is growing to be a health problems globally. However, its specific pathogenesis still needs further exploration. Here we showed that miR-15b was upregulated in the palmitate-induced HepG2 cells and livers of hyperglycemic mice. At the same time, we confirmed that the insulin receptor was a direct target of miR-15b. Then we found that the manipulation of miR-15b expression level could affect the insulin signaling pathway of HepG2 cells and the inhibition of miR-15b in liver of ob/ob mice can improve insulin sensitivity of mice. Furthermore, our study demonstrated that palmitate could upregulate the expression of miR-15b by activating PPARα. Our findings established PPARα-responsive miR-15b as a critical regulator of hepatic insulin signaling, thus serving as a new potential therapeutic target for diabetes.
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KEYWORD
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miR-15b, insulin receptor, insulin resistance, type II diabetes
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